Anti-LIME Monoclonal Antibody (Clone:LIME-10)
Product Sizes
0.1 mg
£581.00
30-1274-0.1MG
About this Product
- SKU:
- 30-1274
- Additional Names:
- LIME1||LIME||LP8067
- translate.label.attr.clone:
- LIME-10
- Clonality:
- Monoclonal
- Extra Details:
- LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain; expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors; LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Interestingly; Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck; thus; LIME serves as a positive regulator of TCR-dependent T cell signaling. However; under some circumstances; LIME may mediate inhibitory signals.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- COOH-terminal peptide comprising residues 281-296 of the human LIME conjugated to keyhole limpet hemocyanin.
- Isotype:
- Mouse IgG2a
- Purification:
- Purified by protein-A affinity chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
