Anti-Lyn Monoclonal Antibody (Clone:LYN-01)
Product Sizes
0.1 mg
£581.00
30-1253-0.1MG
About this Product
- SKU:
- 30-1253
- Additional Names:
- LYN||JTK8
- translate.label.attr.clone:
- LYN-01
- Clonality:
- Monoclonal
- Extra Details:
- Lyn is a Src-family protein tyrosine kinase that is predominantly expressed in hematopoietic cells. It is associated with a number of cell surface receptors including the B cell antigen receptor (BCR) and Fc receptors. Upon their triggering; Lyn phosphorylates subunits of these receptors in a cholesterol-dependent manner; utilizing the plasma membrane lipid raft system. The phosphorylated intracellular domains of the receptors are accessible for cytoplasmic Syk tyrosine kinase; which is activated by Lyn-mediated phosphorylation and which transduces the signal to downstream adaptors. Lyn is abnormally distributed in acute myeloid leukemia cells and seems to be a novel pharmacologic target of this disease.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Bacterially expressed recombinant fragment of human Lyn (aa 8 - 238).
- Isotype:
- Mouse IgG1
- Purification:
- Purified by protein-A affinity chromatography
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
