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Antibodies

Anti-Syk Monoclonal Antibody (Clone:SYK-01)

Product Sizes
0.1 mg
£581.00
30-1252-0.1MG
About this Product
SKU:
30-1252
Additional Names:
SYK
translate.label.attr.clone:
SYK-01
Clonality:
Monoclonal
Extra Details:
Syk is a cytoplasmic protein tyrosine kinase that translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering; and phosphorylates downstream adaptor proteins; thereby providing docking sites for initiation of subsequent signaling pathways; such as calcium mobilization; cytoskeleton remodeling; or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor; which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.
Format:
Purified
Host:
Mouse
Immunogen:
Recombinant fragment (aa 5-360) of human Syk.
Isotype:
Mouse IgG1
Purification:
Purified by protein-A affinity chromatography
Reactivities:
Mouse
Shipping Conditions:
Blue Ice
Storage Conditions:
Store at 2-8[o]C. Do not freeze.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
  • Manufacturer's Data Sheet:1.jpg
Figure 2: Immunofluorescence staining of Syk in human HeLa cell line using anti-Syk (SYK-01; green). Actin cytoskeleton was decorated by phalloidin (red) and cell nuclei stained with DAPI (blue).
Figure 3: Immunocytochemistry analysis of Syk in human primary fibroblasts using anti-Syk (SYK-01; green). Actin cytoskeleton was decorated by phalloidin (red) and cell nuclei stained with DAPI (blue).
Figure 3: Immunocytochemistry analysis of Syk in human primary fibroblasts using anti-Syk (SYK-01; green). Actin cytoskeleton was decorated by phalloidin (red) and cell nuclei stained with DAPI (blue).