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Antibodies

Anti-CD52 / CAMPATH-1 Monoclonal Antibody (Clone:HI186)

Product Sizes
0.1 mg
£551.00
30-1244-0.1MG
About this Product
SKU:
30-1244
Additional Names:
CD52||CDW52||HE5
translate.label.attr.clone:
HI186
Clonality:
Monoclonal
Extra Details:
CD52 (CAMPATH-1; HE5) is a highly glycosylated GPI-anchored 21-28 kDa glycopeptide which is present at high levels on lymphocytes; macrophages; epithelial cells of male reproductive tract and mature sperm. Its 12-amino acid beckbone carries a complex N-linked carbohydrate moiety; which differs between sperm and leukocyte CD52; as well as the GPI anchor does. CD52 can be acquired by sperm cells from seminal plasma; where it is released by epithelial cells. Although CD52 is not an essential T-cell costimulator; its triggering results in activation of normal human T cells. CD52 is a very good target for antibody/complement-mediated cell lysis.
Format:
Purified
Host:
Mouse
Immunogen:
Human tonsil
Isotype:
Mouse IgG2a
Purification:
Purified by protein-A affinity chromatography
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Store at 2-8[o]C. Do not freeze.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
  • Manufacturer's Data Sheet:1.jpg
Figure 2: Separation of human CD52 positive lymphocytes (red-filled) from neutrophil granulocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD52 (HI186) purified antibody (concentration in sample 4 μg/ml) GAM APC.
Figure 3:Flow cytometry analysis of CD52 in patients suffering with Acute Lymphoblastic Leukemia (anti-human CD52 (HI186); detection by Goat anti-mouse IgG2b PE). Fig. 1A €“ CD52 negative pro T ALL (gate leukemic cells) Fig. 1B €“ CD52 positive cALL (gate leukemic cells)
Figure 3:Flow cytometry analysis of CD52 in patients suffering with Acute Lymphoblastic Leukemia (anti-human CD52 (HI186); detection by Goat anti-mouse IgG2b PE). Fig. 1A €“ CD52 negative pro T ALL (gate leukemic cells) Fig. 1B €“ CD52 positive cALL (gate leukemic cells)