Anti-PAG / Cbp Monoclonal Antibody (Clone:MEM-255)
Product Sizes
0.1 mg
£581.00
30-1225-0.1MG
About this Product
- SKU:
- 30-1225
- Additional Names:
- PAG1||CBP||PAG
- translate.label.attr.clone:
- MEM-255
- Clonality:
- Monoclonal
- Extra Details:
- PAG (phosphoprotein associated with GEMs); also known as Cbp (Csk-binding protein); is a ubiquitously expressed 46 kDa transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains); which however migrates on SDS PAGE gels anomalously as an 80 kDa molecule. Following tyrosine phosphorylation by Src family kinases; PAG binds and thereby activates the protein tyrosine kinase Csk; the major negative regulator of the Src family kinases. Signaling via the B-cell receptor in B cells or high affinity IgE receptor (FcepsilonRI) in mast cells leads to PAG increased tyrosine phosphorylation and Csk binding; while T cell receptor signaling causes PAG dephosphorylation; loss of Csk binding and increased activation of the protein tyrosine kinase Lck.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Recombinant intracellular fragment (aa 97-432) of human Cbp (PAG).
- Isotype:
- Mouse IgG2a
- Purification:
- Purified by protein-A affinity chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
