Anti-Lck Monoclonal Antibody (Clone:LCK-01)
Product Sizes
0.1 mg
£561.00
30-1170-0.1MG
About this Product
- SKU:
- 30-1170
- Additional Names:
- LCK
- translate.label.attr.clone:
- LCK-01
- Clonality:
- Monoclonal
- Extra Details:
- Lck is a Src-family tyrosine kinase; which is essential for signaling through the T-cell receptor (TCR) complex. Upon TCR triggering; Lck phosphorylates the ITAM motives in its zeta subunits; establishing binding sites for the SH2 domains of the tyrosine kinase ZAP70; which is also phosphorylated by Lck and thereby activated to generate subsequent signaling platforms by phosphorylation of adaptor LAT. Whereas the majority of Lck is localized to the plasma membrane; there is also a significant fraction associated with the Golgi apparatus; which may contribute to Raf activation under conditions of weak stimulation through the TCR. Lck is also involved in the regulation of apoptosis induced by various stimuli; but not by the death receptors.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Peptide corresponding to amino acids 22-36 in the sequence of human Lck.
- Isotype:
- Mouse IgG1
- Purification:
- Purified by protein-A affinity chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
