Anti-CD47 / Integrin Associated Protein Monoclonal Antibody (Clone:MEM-122)
Product Sizes
0.1 mg
£541.00
30-1130-0.1MG
About this Product
- SKU:
- 30-1130
- Additional Names:
- CD47||MER6
- translate.label.attr.clone:
- MEM-122
- Clonality:
- Monoclonal
- Extra Details:
- CD47 (integrin-associated protein; IAP) is an ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions. Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways; such as activation of heterotrimeric G proteins. Binding secreted thrombospondin-1; CD47 counteracts graft vascularization. CD47 acts also as a ligand for CD172a (signal regulatory protein alpha; SIRP alpha); an immune inhibitory receptor on macrophages; this interaction prevents phagocytosis of CD47-positive cells. Moreover; CD47-CD172a system affects cell migration; B cell adhesion and T cell activation. CD47 is also involved in modulation of chondrocyte responses to mechanical signals; and promotes neuronal development; being especially abundant in synapse-rich regions of brain and retina.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- COS-7 (African green monkey) cells
- Isotype:
- Mouse IgM
- Purification:
- Purified by precipitation and chromatography
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
