Anti-CD43 / Leukosialin Monoclonal Antibody (Clone:MEM-59)
Product Sizes
0.1 mg
£541.00
30-1125-0.1MG
About this Product
- SKU:
- 30-1125
- Additional Names:
- SPN||CD43
- translate.label.attr.clone:
- MEM-59
- Clonality:
- Monoclonal
- Extra Details:
- CD43 (leukosialin; sialophorin) is a transmembrane mucin-like protein with high negative charge; expressed on the surface of most hematopoietic cells. CD43 contributes to a repulsive barrier that interferes with cellular adhesion; however; in certain cases also promotes leukocyte aggregation. By interaction with actin-binding proteins ezrin and moesin CD43 plays a regulatory role in remodeling T-cell morphology and regulates cell-cell interactions during lymphocyte traffic. CD43 signaling both enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors. Expression of CD43 causes induction of functionally active tumour suppressor p53 protein; but in case of p53 and ARF defficiency CD43 promotes tumour proliferation and viability. It appears to be an important modulator of leukocyte functions.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Human T lymphocytes.
- Isotype:
- Mouse IgG1
- Purification:
- Purified by protein-A affinity chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
