Anti-CD274 / PD-L1 Monoclonal Antibody (Clone:29E.2A3)-Biotin Conjugated
Product Sizes
0.1 mg
£568.00
30-1091-B-0.1MG
About this Product
- SKU:
- 30-1091-B
- Additional Names:
- CD274||B7H1||PDCD1L1||PDCD1LG1||PDL1
- translate.label.attr.clone:
- 29E.2A3
- Clonality:
- Monoclonal
- Conjugate:
- Biotin
- Extra Details:
- Specificity: The mouse monoclonal antibody 29E.2A3 recognizes an extracellular epitope of CD274 / PD-L1 (also known as B7-H1); a 40 kDa type I transmembrane protein expressed by dendritic cells; activated T cells; activated monocytes; and in various tissues; above all in heart and skeletal muscle; placenta and lung; and in many cancer cells; including T cell lymphomas; melanomas; and glioblastomas. Desciption: CD274 / PD-L1 (programmed death ligand-1); also known as B7-H1; is a member of the B7 family of regulatory proteins. It can act as both costimulatory and coinhibitory molecule for T cells. Interaction with its ligand CD279 (PD1) appears to be important in the maintenance of peripheral tolerance and in prevention of tumor rejection. Even pathogens (e.g. Schistosoma) may exploit CD274 to evade an immune response. Besides CD279; existence of other receptor(s) for CD274 is likely.
- Host:
- Mouse
- Immunogen:
- Full length human CD274
- Isotype:
- Mouse IgG2b kappa
- Purification:
- Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
