Anti-Cyclin D1 Monoclonal Antibody (Clone:DCS-6)
Product Sizes
0.1 mg
£532.00
30-1084-0.1MG
About this Product
- SKU:
- 30-1084
- Additional Names:
- CCND1; DIP1; GCIP; HHM
- translate.label.attr.clone:
- DCS-6
- Clonality:
- Monoclonal
- Extra Details:
- Cyclin D1 (PRAD1; Bcl-1) is a cytoplasmic and nuclear protein; which is synthesized during G1 phase and assembles with either cyclin-dependent kinase 4 (CDK4) or CDK6 in response to growth factor stimulation. D-type cyclin-CDK complexes act to inactivate the growth-suppressive function of the Rb protein through its phosphorylation; and titrate CDK inhibitors such as p21Cip1 and p27Kip1. Whereas during G1 phase cyclin D1 accumulates in the nucleus; it translocates into the cytoplasm during S phase. Without growth factor-mediated stimulation cyclin D1 is unstable; and undergoes ubiquitin-mediated degradation; which is triggered by its phosphorylation. Cyclin D1 destabilization participates in G1/S phase arrest.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- recombinant human cyclin D1 (amino acids 1-295)
- Isotype:
- Mouse IgG2a
- Purification:
- Purified by protein-A affinity chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
