Recombinant Human TRIM29 His Tag protein
Product Sizes
10µg
£606.00
21-1015-10UG
20µg
£876.00
21-1015-20UG
About this Product
- SKU:
- 21-1015
- Extra Details:
- Source: CHO-K1. TRIM29 (Tripartite motif-containing 29) is a member of the tripartite motif (TRIM) family of transcription factors; characterized by the conserved RING finger; B-box; and coiled-coil domains. The TRIM family has been implicated in a variety of physiologic processes including development; apoptosis and epithelial-mesenchymal transition (EMT). Depending on a tumor types; TRIM29 also may function as an oncogene or a tumor suppressor. As an oncogene; it facilitates tumor cell proliferation and invasion through stabilization of Beta-catenin. The mechanisms may also involve deactivation of p53 activity and promoting cell survival by inhibiting proapoptotic genes regulated by p53. As a histone binding protein TRIM29 is responsible for DDR (DNA damage response). It functions as a scaffold protein to assemble DNA repair proteins into chromatin followed by efficient activation of DDR. TRIM29 binds to modified histone H3 and H4 tails in the context of nucleosomes. Furthermore; chromatin binding of TRIM29 is required for the phosphorylation of H2AX nucleosomes and cell viability in response to ionizing radiation.
- Purification:
- >90% by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- TRIM29 Protein is shipped on ice packs. Upon arrival; Store at -20[o]C. Do not freeze-thaw multiple times.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:21-1015.jpg
