Polyclonal antibody to cIAP-1/HIAP-2
Product Sizes
50 µl
£396.00
20-1114-50UL
About this Product
- SKU:
- 20-1114
- Additional Names:
- BIRC2||API1||IAP2||MIHB||RNF48
- Clonality:
- Polyclonal
- Extra Details:
- cIAP1 (HIAP2; MIHB) is a member of the family of inhibitor of apoptosis proteins (IAP). IAPs suppress mitochondria-dependent and -independent apoptosis by binding to and inhibiting caspases through their BIR domains (reviewed in Liston et al; 2003; Wright and Duckett; 2005). Resistance towards apoptosis is a hallmark of cancer cells; and overexpression of IAPs can contribute to the development of cancer though inhibiting apoptosis. In addition to at least one BIR domain; some IAP members also have a RING-type finger motif at their carboxyl-terminal. The RING finger domain of several IAPs; including cIAP2; have E3 ubiquitin ligase activity and target the degradation of Smac/DIABLO through ubqiuitination. Smac/DIABLO is a death inducer and functions by inhibiting IAP-caspase interactions; thereby promoting apoptosis. Degradation of cell death inducers like Smac/DIABLO is thought to be a conserved mechanism by which IAPs enhance their anti-apoptotic activity; thereby promoting cell survival. The IAPs; including cIAP1; have widespread tissue protein expression; with expression levels and subcellular localization patterns differing depending on the cell lineage (see Vischioni et al. 2005 for a comprehensive study). This antibody recognizes cIAP1; human cIAP1 is a 618 amino acid protein.
- Format:
- Sera
- Host:
- Rabbit
- Immunogen:
- Full-length recombinant protein of human cAIP1 was used as immunogen for this antibody
- Isotype:
- Rabbit IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
