Polyclonal antibody to CARD8 (Tucan)
Product Sizes
50 µl
£396.00
20-1105-50UL
About this Product
- SKU:
- 20-1105
- Additional Names:
- CARD8||KIAA0955||NDPP1
- Clonality:
- Polyclonal
- Extra Details:
- This antibody recognizes TUCAN; a 431 amino acid protein. TUCAN (tumor up-regulated CARD-containing antagonist of caspase nine) also known as CARD8 is a CARD domain containing protein. Proteins containing a CARD (caspase-associated recruitment domain) domain are key regulators of cell death; cell survival and cytokine production. TUCAN is an anti-apoptotic CARD protein that can protect tumors from cell death stimuli; and is overexpressed in certain forms of cancer. TUCAN has been shown to inhibit caspase-9 activation by binding to the CARD region of pro-caspase-9; thereby suppressing the formation of the Apaf-1-caspase-9 apoptotic complex and apoptosis. Additionally; a TUCAN isoform has been described that blocks both caspase-8 and caspase-9 mediated apoptosis. However; in some tumors; TUCAN play a role in modulating NFkB transcription factor survivial signaling pathways.
- Format:
- Sera
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide of human TUCAN (CARD8) (amino acids 125-146 LVGGPLFDVTAEPEEAVAEIHL) was used as immunogen for this antibody
- Isotype:
- Rabbit IgG
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
