Polyclonal antibody to TRAF-2
Product Sizes
50 µl
£396.00
20-1096-50UL
About this Product
- SKU:
- 20-1096
- Additional Names:
- TRAF2||TRAP3
- Clonality:
- Polyclonal
- Extra Details:
- This antibody recognizes TRAF2; which is a member of TRAF (TNF receptor-associated factor) adapter proteins composed 501 amino acids. It Links TNFRs (TNF Receptors) to the SAPKs (Stress-Activated Protein Kinases) and p38s. TRAF2 can activate ASK1 (Apoptosis Signal-Regulating Kinase-1) in vivo and can interact in vivo with the amino- and carboxyl-terminal noncatalytic domains of the ASK1 polypeptide. Expression of the amino-terminal noncatalytic domain of ASK1 can inhibit TNF and TRAF2 activation of SAPK. TRAF2 is a potential mediator of CD40 signaling. In vitro; TRAF2 and TRAF3 bind to the CD40 Cytoplasmic Tail (CD40CT) with much higher affinity than TRAF5 and TRAF6 (TNF Receptor Associated Factor-6) and that TRAF2 and TRAF3 bind to different residues of the CD40CT. The TRAF2-binding site of the CD40CT is critical for NF-KappaB and SAPK activation; as well as the UP-regulation of the ICAM1 (Intercellular Adhesion Molecule-1).
- Format:
- Sera
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide of human TRAF-2 ( amino acids 6-31 VTPPGSLELLQPGFSKTLLGTKLEAK) was used as immunogen for this antibody
- Isotype:
- Rabbit IgG
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
