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Antibodies

Polyclonal antibody to SMAC/Diablo

Product Sizes
50 µl
£396.00
20-1089-50UL
About this Product
SKU:
20-1089
Additional Names:
DIABLO||SMAC
Clonality:
Polyclonal
Extra Details:
Smac/DIABLO (second mitochondrial-derived activator of caspase/direct IAP binding protein with low pI) is encoded by the nucleus and resides as a precursor within the intermembranous space of the mitochondria. During apoptosis; Smac/DIABLO is proteolytically cleaved and released from the mitochondria into the cytosol; where it promotes cell death by interacting with IAPs and inhibiting their anti-apoptotic function. In turn; certain IAPs may degrade Smac/DIABLO and block its cell death function. Smac/DIABLO is expressed in a wide range of normal tissues and some tumor cells lines; and its over-expression in tumor cell lines can trigger both extrinsic and intrinsic apoptosis pathways.
Format:
Sera
Host:
Rabbit
Immunogen:
A Full-length recombinant protein of human SMAC was used as immunogen for this antibody
Isotype:
Rabbit IgG
Reactivities:
Human, Mouse, Rat
Shipping Conditions:
Blue Ice
Storage Conditions:
Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
Supplier:
Abeomics
Type:
Antibodies:Polyclonal Antibody
  • Manufacturer's Data Sheet:1.jpg
Fig:2 Formalin-fixed; paraffin-embedded tissue section of human plasmacytoma (a mature B cell lymphoma) stained for Smac/DIABLO using 20-1089 at 1:2000. Intense nuclear staining is observed. Hematoxylin-eosin counterstain
Fig:3 Formalin-fixed; paraffin-embedded human colon stained for Smac/DIABLO using 20-1089 at 1:2000. A; normal colon. B and C; colon carcinoma. Only trace Smac/DIABLO immunoreactivity is seen in normal colonic epithelium (A); which is seen in the apical; foveolar cells. In contrast; strong immunoreactivity is observed in nuclear (B) and cytoplasmic (C) locations in the colon carcinoma specimen. Hematoxylin-eosin counterstain.
Fig:3 Formalin-fixed; paraffin-embedded human colon stained for Smac/DIABLO using 20-1089 at 1:2000. A; normal colon. B and C; colon carcinoma. Only trace Smac/DIABLO immunoreactivity is seen in normal colonic epithelium (A); which is seen in the apical; foveolar cells. In contrast; strong immunoreactivity is observed in nuclear (B) and cytoplasmic (C) locations in the colon carcinoma specimen. Hematoxylin-eosin counterstain.