Polyclonal antibody to RIP
Product Sizes
50 µl
£396.00
20-1083-50UL
About this Product
- SKU:
- 20-1083
- Additional Names:
- AGFG1||HRB||RAB||RIP
- Clonality:
- Polyclonal
- Extra Details:
- RIP (Receptor Interacting Protein) is a 74 kD Ser/Thr kinase which interacts with CD95 (Fas/APO1) receptor and the tumor necrosis factor receptor (TNFR1). It is a cell death domain adapter protein which can bind to the adapter proteins TRADD; RAID (CRADD) and TRAF2. RIP contains an N terminal region with homology to protein kinases; an intermediate domain capable of association with MAPKKK and a C terminal region containing an intracellular death domain motif. RIP activates both p38 MAP Kinase and SAPK families. In vitro; RIP induces apoptosis; as well as SAPK/JNK and NF-kB activation. NF-kB activation through TRADD; TRAF2 and RIP can be triggered also by DR3/APO3 upon activation with APO3/Tweak ligand. DR4 and DR5 also use FADD; TRADD; and RIP in their signal transduction pathways. RIP deficient mice fail to thrive; displaying extensive apoptosis in both lymphoid and adipose tissues and dying at 1-3 days of age. RIP possesses kinase activity as it autophosphorylates itself on serine and threonine residues.
- Format:
- Sera
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide of human RIP1 (amino acids 269-287 EANPEARPTFPGIEEKFRP) was used as immunogen for this antibody
- Isotype:
- Rabbit IgG
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
