Polyclonal antibody to Livin (KIAP)
Product Sizes
50 µl
£396.00
20-1069-50UL
About this Product
- SKU:
- 20-1069
- Additional Names:
- BIRC7||KIAP||LIVIN||MLIAP||RNF50||UNQ5800/PRO19607/PRO21344
- Clonality:
- Polyclonal
- Extra Details:
- This antibody recognizes Livin; both isoform alpha and isoform beta. Human Livin isoform alpha is a 298 amino acid protein. Livin (BIRC7/KIAP) is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. Some IAP members; like Liven; also have a RING-type finger motif at their carboxyl-terminal which may enhance anti-apoptotic activity. Many RING finger-containing IAPs possess E3 ubiquitin ligase activity; and it has been shown that Liven acts an E3 ubiquitin ligase for targeting the degradation of Smac/DIABLO. Thus degradation of Smac/DIABLO is thought to be a mechanism to enhance Livin anti-apoptotic activity; thereby promoting cell survival. Two splicing variants of Livin; alpha and beta; have been identified. The two isoforms are thought to have different anti-apoptotic properties; however; there are conflicting reports are to whether they actually differ in their biological activities. Liven is expressed at low levels in adult tissues; and relatively higher levels in developmental tissues and in many cancer cells. Certain cancers patients develop autoantibodies against liven and in a number of cancers; Liven is detected only in the tumors but not; or to substantially lower levels; in the corresponding normal adjacent tissue.
- Format:
- Sera
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide of human Livin; isoform alpha and isoform beta (amino acids 199-217 PELPTPRREVQSESAQEPG) was used as immunogen for this antibody
- Isotype:
- Rabbit IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
