Polyclonal antibody to CARD12 (IPAF/ClAN)
Product Sizes
50 µl
£396.00
20-1067-50UL
About this Product
- SKU:
- 20-1067
- Additional Names:
- NLRC4||CARD12||CLAN||CLAN1||IPAF||UNQ6189/PRO20215
- Clonality:
- Polyclonal
- Extra Details:
- Ipaf (also known as Clan/CARD12/NLRC4) is a CARD domain containing protein belongs to the NLR family. In general CARD proteins are implicated in host defense against infection; environmental stress or cellular damage. CARD domains are homotypic protein interaction motifs that enable networks of proteins to communicate via CARD-CARD interactions. There are at least three major signaling pathways in which CARD proteins act: (1) Regulation of caspase activation in the context of apoptosis (2) Regulation of caspase activation in the context of inflammation (3) Regaultion of NF-kB activation in the context of innate or adaptive immune responses. Ipaf plays a role in regulating caspase-1 activity; which in turn mediates the maturation of inflammatory cytokines IL-1b and IL-18. In transfected cells; Ipaf has been shown to directly interact with procaspase-1 and induce proteolytic activation of procaspase-1 in transfected cells. On the flip side; macrophages from IPAF deficient mice failed to activate caspase-1 in response to Salmonella typhimurium infection underscoring the importance of IPAF in vivo. IPAF also interact with the pro-apoptotic adaptor protein ASC and co-expression of IPAF with ASC has been shown to induce NF-kB activation and apoptosis.
- Format:
- Sera
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide of human IPAF/ClAN/CARD12 (amino acids 971-989 DFSTKEFLPDPALVRKLSQ) was used as immunogen for this antibody
- Isotype:
- Rabbit IgG
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
