Polyclonal antibody to FLIP
Product Sizes
50 µl
£396.00
20-1065-50UL
About this Product
- SKU:
- 20-1065
- Additional Names:
- CASH|| CASP8AP1||CLARP||MRIT
- Clonality:
- Polyclonal
- Extra Details:
- This antibody recognizes FLIP long and short; isoforms that contain the peptide immunogen sequence (DRKAVETHLLRNPHLVSD). Human FLIP is a 480 amino acid protein which contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and 10; and potently inhibits apoptosis induced by death receptors.However; the functions of FLIP remain to be fully elucidated and there is some evidence FLIP may also act as an activator of caspase-8/-10 in certain cases; thereby taking on an apoptosis promoting role.Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the caspase (ICE/CED-3) protease family. Most if not all; forms of apoptosis involve activation of the caspases. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the caspase family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP; respectively. The human FLIP was also cloned by several labs independently and termed Casper ; I-FLICE; FLAME-1; CASH and CLARP3-7.
- Format:
- Sera
- Host:
- Rabbit
- Immunogen:
- A synthetic peptideof human FLIP (amino acids 75-92 DRKAVETHLLRNPHLVS) was used as immunogen for this antibody
- Isotype:
- Rabbit IgG
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
