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Antibodies

Polyclonal antibody to PTPN13/PTPL1 (FAP1)

Product Sizes
50 µl
£396.00
20-1063-50UL
About this Product
SKU:
20-1063
Additional Names:
PTPN13||PNP1||PTP1E||PTPL1
Clonality:
Polyclonal
Extra Details:
This antibody recognizes FAP-1; including FAP-1 isoforms; FAP-1 (also known as Fas-associated phosphatase-1; PTPN13; PTP-BAS; hPTPIE; and PTPL1) is a member of the protein tyrosine phosphatase (PTP) family. FAP-1 phosphatase is thought to be important in the Fas signaling pathway. FAP-1 binds to the cytosolic tail of the Fas receptor (Apo1; CD95) and inhibits Fas-induced apoptosis. Increased FAP-1 protein levels in some tumor cell lines and tumor tissues correlates with resistance to Fas-mediated apoptosis. In general; FAP-1 expression has been found to be highest in cell lines and tissues that are relatively resistant to Fas-mediated apoptosis. Gene transfer-mediated elevations in FAP-1 partially abolished Fas-induced apoptosis in a T cell line which is consistent with an inhibitory effect of FAP-1 on Fas signal transductions. Additionally; FAP-1 expression correlates with Fas resistant in ovarian cancer cell lines and FAP-1 is commonly expression in ovarian cancers.
Format:
Sera
Host:
Rabbit
Immunogen:
A recombinant protein of human FAP-1 (amino acids 1279 to 1883) was used as immunogen for this antibody
Isotype:
Rabbit IgG
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
Supplier:
Abeomics
Type:
Antibodies:Polyclonal Antibody
  • Manufacturer's Data Sheet:1.jpg
Fig:2 Immunohistochemisty of FAP-1 in formalin-fixed; paraffin embedded ovarian carcinoma cores from a tissue microarray using 20-1063 at 1:2000. A-D; samples are from four different patients. A1-D1 are high magnification images from A-D; respectively. Hematoxylin-eosin counterstain.
Fig:3 Immunocytochemical analysis of FAP-1 in cell lines using 20-1063 at 1:2000. In ovarian carcinoma cell lines FAP-1 expression was detected in SK-OV-3 and OVCAR-3; but not in BG-1 or HEY. Human 293 kidney and Jurkat T cell lines were used as positive and negative controls; respectively. The staining data correlates with the western blot data (figure to the left).
Fig:3 Immunocytochemical analysis of FAP-1 in cell lines using 20-1063 at 1:2000. In ovarian carcinoma cell lines FAP-1 expression was detected in SK-OV-3 and OVCAR-3; but not in BG-1 or HEY. Human 293 kidney and Jurkat T cell lines were used as positive and negative controls; respectively. The staining data correlates with the western blot data (figure to the left).