Polyclonal antibody to cIAP-2/HIAP-1
Product Sizes
50 µl
£396.00
20-1057-50UL
About this Product
- SKU:
- 20-1057
- Additional Names:
- BIRC2||API1||IAP2||MIHB||RNF48
- Clonality:
- Polyclonal
- Extra Details:
- This antibody recognizes cIAP2; human cIAP2 is a 604 amino acid protein.This also recognize AP12-MALT1 fusion proteins assuming that they contain the cIAP2 peptide sequence (QDFSALMRSSYHCAMNNENAR) used for immunogen.This protein is a member of the family of inhibitor of apoptosis proteins (IAP). IAPs suppress mitochondria-dependent and -independent apoptosis by binding to and inhibiting caspases through their BIR domains. The RING finger domains of several IAPs; including cIAP2; have E3 ubiquitin ligase activity and target the degradation of Smac/DIABLO through ubqiuitination. Degradation of cell death inducers like Smac/DIABLO is thought to be a conserved mechanism by which IAPs enhance their anti-apoptotic activity; thereby promoting cell survival. Several variants of the API2-MALT1 fusion proteins can occur in MALT1 lymphoma patients depending on the chromosomal breakpoints. It is thought that AP12-MALT1 can enhance the activation of NK-kB signalling; which may be relevant to the pathology of MALT lymphomas.
- Format:
- Sera
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide human of cIAP-2 protein (amino acids 152-172 QDFSALMRSSYHCAMNNENAR) was used as the immunogen for this antibody
- Isotype:
- Rabbit IgG
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
