Polyclonal antibody to cIAP-2/HIAP-1
Product Sizes
50 µl
£396.00
20-1056-50UL
About this Product
- SKU:
- 20-1056
- Additional Names:
- BIRC2||API1||IAP2||MIHB||RNF48
- Clonality:
- Polyclonal
- Extra Details:
- This antibody recognizes cIAP2;which is a 604 amino acid protein belongs to the family of inhibitor of apoptosis proteins (IAP). Resistance towards apoptosis is a hallmark of cancer cells; and overexpression of IAPs can contribute to the development of cancer though inhibiting apoptosis. IAPs suppress mitochondria-dependent and -independent apoptosis by binding to and inhibiting caspases through their BIR domains. In addition to BIR domain; some IAP members also have a RING-type finger motif at their carboxyl-terminal. Smac/DIABLO is a death inducer and functions by inhibiting IAP-caspase interactions; thereby promoting apoptosis. Degradation of cell death inducers like Smac/DIABLO is thought to be a conserved mechanism by which IAPs enhance their anti-apoptotic activity; thereby promoting cell survival. The IAPs; including cIAP2; have widespread tissue protein expression; with expression levels and subcellular localization patterns differing depending on the cell lineage.
- Format:
- Sera
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide human cIAP-2 protein (amino acids 532-549 KYIPTEDVSDLPVEEQLR) was used as the immunogen for this antibody
- Isotype:
- Rabbit IgG
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
