Polyclonal antibody to CD40/TNFRSF5
Product Sizes
50 µl
£396.00
20-1053-50UL
About this Product
- SKU:
- 20-1053
- Additional Names:
- CD40||TNFRSF5
- Clonality:
- Polyclonal
- Extra Details:
- CD40 and its ligand CD154 are members of the tumor necrosis factor receptor (TNFR) and TNF families; respectively; that play key roles in signaling pathways mediating cell growth; survival and differentiation in B-lymphocytes. The CD40 receptor is a 45-50 kDa glycoprotein and is expressed on the surface of B-lymphocytes; some activated T-cells; monocytes; follicular dendritic cells; basal epithelial cells; and in some epithelial and non-epithelial carcinomas.The functions of CD40 have been most extensively studied in B-cells. Several distinct structural motifs in the CD40 cytoplasmic domain regaulate various CD40 signaling pathways. A major CD40 signaling pathway activated from CD154 ligand binding is the canonical pathway to the transcription factor family NFkB; a family of genes mediating immune and inflammatory responses.Although CD40 has been extensively studied as a plasma membrane-associated growth factor membrane receptor. it has also been identified in the cytoplasm and nucleus of normal and neoplastic B-lymphoid cells. The presence of CD40 in the nucleus of activated normal B lymphocytes and neoplastic B-lymphoid cells suggests that CD40 may play a more complex role in regulating essential growth and survival pathways in B-lymphocytes than previously thought.
- Format:
- Sera
- Host:
- Rabbit
- Immunogen:
- A recombinant protein containing the short cytoplasmic domain of the human CD40 molecule was used as immunogen for this antibody
- Isotype:
- Rabbit IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
