Polyclonal antibody to Caspase-9
Product Sizes
50 µl
£396.00
20-1044-50UL
About this Product
- SKU:
- 20-1044
- Additional Names:
- CASP9||MCH6
- Clonality:
- Polyclonal
- Extra Details:
- Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6; Mch6; and Apaf-3. Caspase-9 and Apaf-1 bind to each other; which leads to caspase-9 activation. Caspase-9 is also activated by granzyme B and CPP32. Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases; being responsible for the proteolytic cleavage of many key proteins in apoptosis. Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFalpha; TRAIL; anti-CD-95; FADD; and TRADD. Caspase-9 is expressed in a variety of human tissues. The Cleaved Caspase-9 polyclonal antibody preferntially recognizes (active) cleaved Caspase-9. Whereas the antibody has a strong preference for (active) cleaved Caspase-9; in some cell or tissue systems or techniques the antibody may also recognize the pro form of Caspase-9.
- Format:
- Sera
- Host:
- Rabbit
- Immunogen:
- A recombinant catalytically active of human Caspase-9 protein was used as the immunogen for this antibody
- Isotype:
- Rabbit IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
