Polyclonal antibody to Caspase-3 (Pro and Active)
Product Sizes
50 µl
£396.00
20-1039-50UL
About this Product
- SKU:
- 20-1039
- Additional Names:
- Apopain; Cysteine protease CPP32; Protein Yama; SREBP cleavage activity 1; CPP32
- Clonality:
- Polyclonal
- Extra Details:
- Apoptosis; or programmed cell death; is a common property of all multicellular organisms. The current dogma of apoptosis suggests that the components of the core cell-death machinery are integral to cells and widely conserved across species. Caspases; a family of cysteinyl aspartate-specific proteases; are integral components of the cell death machinery (reviewed in Siegal; 2006; and Lavrik et al; 2005). They play a central role in the initiation and execution of apoptotic cell death and in inflammation. Caspases are typically divided into 3 major groups; depending on the structure of their prodomain and their function. Group 1: inflammatory caspases (caspases 1; 4; 5; 11; 12; 14). Group II: initiator of apoptosis caspases (caspases 2; 8; 9). Group II: effector caspases (caspases 3; 6; 7). Caspases are synthesized as zymogens (inactive pro enzyme precursors which require a biochemical change to become active enzymes) with an N-terminal prodomain of variable length followed by a large subunit (p20) and a small subunit (p10). Caspases are activated through proteolytic cleavage at specific asparagine residues that are located within the prodomain; the p10; and p20 subunits. Activation results in the generation of mature active caspases that consist of the heterotetramer p202-p102. Active caspases mediate cell death and inflammation through cleavage of particular cellular substrates that are involved in these processes. The Caspase-3 polyclonal antisera recognizes the proform of caspase-3 (approx. 32) kDa); and the large (approx. 14-21 kDa) and small (approx. 10 kDa) subunits of active/cleaved Caspase-3.
- Format:
- Sera
- Host:
- Rabbit
- Immunogen:
- A full-length recombinant protein of human Caspase-3 (pro-form) was used as immunogen for this antibody (Dog; Gerbil; Mouse; Rat not tested in western. 90% sequence homology.)
- Isotype:
- Rabbit IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
