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Antibodies

Polyclonal antibody to Bag-1

Product Sizes
50 µl
£396.00
20-1012-50UL
About this Product
SKU:
20-1012
Additional Names:
Bcl-2-associated athanogene 1; HAP
Clonality:
Polyclonal
Extra Details:
This antibody recognizes both BAG-1 and BAG-1 isoforms which contain the peptide immunogen sequence; including BAG-1L. Mouse BAG-1 is a 219 amino acid (aa) protein. The BAG family contains at least six family members; including BAG-1 and its various isoforms [including BAG-1S ; BAG-1M (RAP46/HAP46); and BAG-1L; BAG2; BAG3 (CAIR-1; Bis;); BAG4 (SODD); BAG5 and BAG6 (Scythe; BAT3). The BAG proteins are a family of chaperone regulators that modulate a number of diverse processes including proliferation; survival; stress responses; tumorigenesis; neuronal differentiation; growth arrest and apoptosis. BAG proteins have been characterized as co-chaperones and interact with the chaperone heat shock proteins 70; both constitutive Hsc70 and inducible Hsp70. BAG proteins bind through their BAG domain to the ATPase domain of Hsc70/Hsp70; and can modulate either positively or negatively the functions of the Hsc70/Hsp70 chaperone proteins. The BAG domain has been shown to contribute to the anti-apoptotic activity of BAG- family proteins. The anti-apoptotic activities of BAG-family proteins may be dependent on their interactions with Hsc70/Asp70 and/or binding to Bcl-2. In addition to the conserved BAG domain; BAG-family proteins also contain additional domains which enable them to interact with specific target proteins or to target them to specific locations within cells.
Format:
Sera
Host:
Rabbit
Immunogen:
A synthetic peptide of Bag-1 protein (amino acids 26-45 NERYDLLVTPQQGNSEPVVQD) was used as the immunogen for this antibody
Isotype:
Rabbit IgG
Reactivities:
Human, Mouse, Rat
Shipping Conditions:
Blue Ice
Storage Conditions:
Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
Supplier:
Abeomics
Type:
Antibodies:Polyclonal Antibody
  • Manufacturer's Data Sheet:1.jpg
Fig:2 Formalin-fixed; paraffin-embedded human breast tissue stained for BAG-1 expression using 20-1012 at 1:2000. A. normal breast epithelium. B. breast cancer. A1 and B1 are high magnifications from A and B; respectively. Hematoxylin-eosin counterstain.
Fig:3 Formalin-fixed; paraffin-embedded mouse ischemic brain stained for BAG-1 expression using 20-1012 at 1:2000. A1 is a higher magnification of A. Differential Bag1 expression levels are seen in the hypothalmic nuclei. The variation in expression levels from lack of Bag1 staining to strong staining may be linked to differential responses of the hypothalmic nuclei to ischemic stress. Hematoxylin-eosin counterstain.
Fig:3 Formalin-fixed; paraffin-embedded mouse ischemic brain stained for BAG-1 expression using 20-1012 at 1:2000. A1 is a higher magnification of A. Differential Bag1 expression levels are seen in the hypothalmic nuclei. The variation in expression levels from lack of Bag1 staining to strong staining may be linked to differential responses of the hypothalmic nuclei to ischemic stress. Hematoxylin-eosin counterstain.