Polyclonal antibody to ASC/TMS1
Product Sizes
50 µl
£396.00
20-1005-50UL
About this Product
- SKU:
- 20-1005
- Additional Names:
- PYCARD||ASC||CARD5||TMS1
- Clonality:
- Polyclonal
- Extra Details:
- ASC [apoptosis-associated speck-like protein containing a CARD (caspase-recruitment domain)] is a bimodel protein containing a pyrin/paad domain (PYD/PAAD) and a caspase recruitment domain (CARD) ASC is also known as TMS1 (target of methylation-induced silencing). In general proteins; like ASC/TMS1; containing PYD/PAAD and CARD domains play key roles in regulating apoptosis and inflammation signaling pathways. Mutations in a number of PYD/PAAD- and CARD-containing proteins have been linked to inflammatory diseases and cancer. There is evidence that ASC/TMS1 has roles in both apoptosis and inflammation signaling pathways.With respect to inflammation; ASC/TMS1 interacts with the CARD of procaspase-1 and induces aggregation of a protein complex called the inflammasome; thereby regulating caspase-1 activation and secretion of IL-1b. Additionally; ASC/TMS1 has been found to be subjected to methylation-mediated silencing in a significant proportion of human breast tumors and other cancers; including melanomas; glioblastomas; non-small lung cancers; gastric and colorectal cancers. The loss of ASC/TMS1 expression in breast tumors and other cancers through methylation-mediated (epigenetic) silencing suggests that ASC/TMS1 has a role in tumorigenesis. In general; it is thought that methylation-mediated gene silencing contributes to tumorigenesis by inactivating genes involved in tumor suppression; and by conferring resistance to cell death signals by silencing genes that promote apoptosis. Thus methylation-mediated silencing of ASC/TMS1 may confer a survival advantage to tumor cells by enabling them to escape apoptosis. However; the precise role of ASC/TMS1 in the pathogenesis of cancer remains to be fully elucidated.
- Format:
- Sera
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide of ASC/TMS1 protein (amino acids 83-102 GQLQAATHQGSGAAPAGIQA) was used as the immunogen for this antibody
- Isotype:
- Rabbit IgG
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:20-1005.jpg
