Polyclonal antibody to APAF-1
Product Sizes
50 µl
£396.00
20-1002-50UL
About this Product
- SKU:
- 20-1002
- Additional Names:
- APAF1||KIAA0413
- Clonality:
- Polyclonal
- Extra Details:
- Apaf 1 (apoptosis protease-activating factor-1) is a key regulator of the mitochondrial apoptotic pathway; being the central element of the multimeric apoptosome. The apoptosome consists of cytochrome c; procaspase-9 and seven Apaf 1 monomers; and is considered to be core apoptotic machinery that executes mitochondria-dependent apoptosis. Cytochrome c; normally compartmentalized in the mitochorndria; is released into the cytoplasm following apoptotic stimuli. Apaf 1 binds cytochrome c in the cytoplasm and in the presence of dATP/ATP forms the apoptosome.The apoptosome binds procaspase-9 and promotes its autocatalytic activation.Active caspase-9; in turn; activates downstream caspases including 3; 6; and 7 contributing to the proteolytic caspase activation cascade which leads to cell death.
- Format:
- Sera
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide of APAF-1 protein (amino acids 264-282 GPKYVVPVESSLGKEKGLE) was used as the immunogen for this antibody
- Isotype:
- Rabbit IgG
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
