Mycophenolic acid
Product Sizes
100 mg
£294.00
15-4011-100MG
500 mg
£422.00
15-4011-500MG
About this Product
- SKU:
- 15-4011
- Additional Names:
- MPA; NSC 129185; Ly 68618; Mycophenolate
- Extra Details:
- Isolated from Penicillium brevi-compactum.Antibiotic [1]. Shows antiviral; antifungal and antitumor properties [1; 2]. Immunosuppressive drug used to prevent rejection in organ transplantation; rheumatoid arthritis; and psoriasis [3-6; 13]. Potent reversible inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH); leading to depletion of GMP and interruption of the de novo synthesis of purine nucleotides necessary for B and T lymphocyte proliferation [7; 8]. Inhibits the type II IMPDH isoform (IMPDH-2) 5-fold more potently compared to type I isoform [11]. Inhibits RNA and DNA synthesis [13]. Inducible nitric oxide synthase (iNOS/NOS II) inhibitor [8; 10]. Apoptosis and necrosis inducer [9; 12]. Novel type of inhibitor against RNA guanylyltransferases [14]. Inhibits TNF-Alpha-stimulated MAPK/NF-kB and ROS generation [15]. Autophagy suppressor. Broad-spectrum antiviral compound with inhibitory activity against different coronavirus; including SARS-CoV; MERS-CoV and SARS-CoV-2; cause of COVID-19. It binds to the active site of SARS-CoV-2 papain-like protease (PLpro) possibly inhibiting viral replication.
- Purification:
- >=98% (HPLC; TLC)
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Stable for at least 2 years after receipt when stored at +4[o]C.
- Supplier:
- Abeomics
- Type:
- Biomaterials
- Manufacturer's Data Sheet:download_pdf.php
