Simeprevir (sodium salt)
Product Sizes
1 mg
£210.00
15-4005-1MG
5 mg
£386.00
15-4005-5MG
About this Product
- SKU:
- 15-4005
- Extra Details:
- Molecular Formula: C38H47N5O7S2 . XNa Molecular Weight: 749.9 Simeprevir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease (Ki = 0.36 nM); a serine protease essential for HCV replication.It inhibits HCV viral replication with an EC50 value of 7.8 nM in Huh7 replicon cells using a luciferase-based assay. Simeprevir is effective against the HCV genotypes 1a and 1b in biochemical assays.In Huh7 replicon cells;it is synergistically effective when used in combination with IFN-alpha or NM-107 and has an additive effect when used with ribavirin (Item No. 16757). Formulations containing simeprevir have been used; alone or in combination with pegylated IFN-alpha and ribavirin; for the treatment of HCV.
- Purification:
- >=98%
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C; product is stable for at least two years.
- Supplier:
- Abeomics
- Type:
- Biomaterials
- Manufacturer's Data Sheet:1.png
