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STAT3 Leeporterâ„¢ GFP Reporter-HEK293 Cell Line

Product Sizes
1 Vial
£2747.00
14-702ACL-1VIAL
About this Product
SKU:
14-702ACL
Extra Details:
The STAT Leeporter™ GFP Reporter cell line is a stably transfected HEK293 cell line; which expresses enhanced green fluorescent protein (eGFP) reporter gene under the transcriptional control of the STAT3 responsive promoter; so that the cell line is designed to measure the transcriptional activity of STAT3. As a transcription factor; Signal Transducer and Activator of Transcription 3 (STAT3) is activated through phosphorylation at tyrosine 705 in response to various cytokines including IL-6; interferons; epidermal growth factor; hepatocyte growth factor and leukemia inhibitory factor. The phosphorylated STAT3 forms homodimers or heterodimers with STAT1; and the dimers translocate to nucleus in which DNA binding/promoter induction occurs. The cell line is designed to analyze by fluorescence microscopy and flow cytometry. The STAT3 induction by IL-6 is shown in Figures 1 and 2.
Shipping Conditions:
Blue Ice
Storage Conditions:
Immediately upon receipt; store in liquid nitrogen.
Supplier:
Abeomics
Type:
Cells:Cell Lines
Fig-2: Induction of STAT3 activity by IL-6 in STAT3 Leeporterâ„¢ GFP reporter-HEK293 cells was analyzed by flow cytometry. IL-6 was treated at 0.001; 0.01; 0.1; 1; 10 and 100 ng/ml as noted. Vehicle control (Black line; empty); IL-6 treatment (Green line; grey-filled).
Fig-2: Induction of STAT3 activity by IL-6 in STAT3 Leeporterâ„¢ GFP reporter-HEK293 cells was analyzed by flow cytometry. IL-6 was treated at 0.001; 0.01; 0.1; 1; 10 and 100 ng/ml as noted. Vehicle control (Black line; empty); IL-6 treatment (Green line; grey-filled).