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TLR8/HEK293 Stable Cell Line

Product Sizes
1 Vial
£2747.00
14-537ACL-1VIAL
About this Product
SKU:
14-537ACL
Extra Details:
TLR8/HEK293 Stable Cell Line is a stably transfected HEK293 cell line which expresses human Toll-like receptor 8 (TLR8; also designated as CD288). TLR8 mediates immune responses by recognition of single-stranded RNA of viruses and involves in the pathogenesis of ovarian cancer and lymphoma. TLR8 also responds to synthetic small molecules such as imiquimod and resiquimod (aka R-848) which act as immunomodulators. Note that TLR8 in the TLR8/HEK293 stable cell line contains the N-terminal HA tag (Figure 2); which does not interfere with TLR8 activity as confirmed by functional assay (Figure 1). Sequence data: Human TLR8 (accession number NP_057694) MKESSLQNSSCSLGKETKKENMFLQSSMLTCIFLLISGSCELCA EENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQ GLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPS GLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETL TNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCP RCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVL DLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHL RGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISP LVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSL NSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNAS ALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLE SKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPA SLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHN RISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDI GDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFI TTMVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDW VINELRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSW NFKTAFYLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEG LFWQTLRNVVLTENDSRYNNMYVDSIKQY
Shipping Conditions:
Blue Ice
Storage Conditions:
Immediately upon receipt; store in liquid nitrogen.
Supplier:
Abeomics
Type:
Cells:Cell Lines
Fig-2: Western blot analysis of TLR8 expression in the TLR8/HEK293 cell line. Cell lysates were analyzed by SDS-PAGE followed by Western blotting using anti-HA antibody. Note that TLR8 in the TLR8/HEK293 stable cell line contains the N-terminal HA tag. Control; parental HEK293 cell lysate; TLR8; TLR8/HEK293 cell lysate.
Fig-2: Western blot analysis of TLR8 expression in the TLR8/HEK293 cell line. Cell lysates were analyzed by SDS-PAGE followed by Western blotting using anti-HA antibody. Note that TLR8 in the TLR8/HEK293 stable cell line contains the N-terminal HA tag. Control; parental HEK293 cell lysate; TLR8; TLR8/HEK293 cell lysate.