TLR4/HEK293 Stable Cell Line
Product Sizes
1 Vial
£2747.00
14-533ACL-1VIAL
About this Product
- SKU:
- 14-533ACL
- Extra Details:
- TLR4/HEK293 Stable Cell Line is a stably transfected HEK293 cell line which expresses human Toll-like receptor 4 (TLR4; also designated as CD284). TLR4 mediates immune responses by recognition of lipoplysaccharides (LPS) with the help of LPS-binding protein; CD14 and MD-2. TLR4 stimulation uniquely triggers two signaling pathways named the MyD88-dependent pathway and the TRIF-dependent pathway; which lead to the production of two sets of cytokines such as proinflammatory cytokines and type I interferons/chemokines; respectively. Note that TLR4 in the TLR4/HEK293 stable cell line contains the N-terminal HA tag (Figure 2); which does not interfere with TLR4 activity as confirmed by functional assay (Figure 1). Sequence data: Human TLR4 (accession number NP_612564) MMSASRLAGTLIPAMAFLSCVRPESWEPCVEVVPNITYQCMELN FYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLS HLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHN LIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFI QPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSA LEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQH LELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCS QSDFGTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLI YLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQL EQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQH FPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVERMECATPSDKQGMPVLSLN ITCQMNKTIIGVSVLSVLVVSVVAVLVYKFYFHLMLLAGCIKYGRGENIYDAFVIYSS QDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIIHEGFHKSRKVIVVVSQH FIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRNTYLEWE DSVLGRHIFWRRLRKALLDGKSWNPEGTVGTGCNWQEATSI
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Immediately upon receipt; store in liquid nitrogen.
- Supplier:
- Abeomics
- Type:
- Cells:Cell Lines
- Manufacturer's Data Sheet:14-533ACL_HEK-TLR4_F1.png
