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CD27/NF-kB Leeporterâ„¢ Luciferase Reporter-Jurkat Cell Line

Product Sizes
1 Vial
£3469.00
14-151ACL-1VIAL
About this Product
SKU:
14-151ACL
Extra Details:
The CD27/NF-kB Leeporterâ„¢ Luciferase Reporter cell line is a stably transfected Jurkat cell line which expresses full-length human CD27 along with the Renilla luciferase reporter gene under the transcriptional control of the NF-kB response element. CD27 is a tumor necrosis factor (TNF) receptor superfamily member found on T cells; B cells and NK cells. It binds to its ligand; CD70; which is present on activated lymphocytes and dendritic cells; triggering a co-stimulatory signal that facilitates T cell activation; survival and proliferation. Targeting the CD27/CD70 pathway has emerged as a promising therapeutic approach for treating both innate and adaptive immune disorders; as well as cancer.
Shipping Conditions:
Blue Ice
Storage Conditions:
Immediately upon receipt; store in liquid nitrogen.
Supplier:
Abeomics
Type:
Cells:Cell Lines
Fig-2: Activation of CD27 signaling pathway. CD27 in the Jurkat/NF-kB/hCD27 Reporter Cell Line was activated by CD70 stably expressed in hCD70/CHO-K1 Cell Line (Cat. No. 14-543ACL) in a dose-response manner. Note: Jurkat/NF-kB reporter cell line (Abeomics; Cat. No. 14-142ACL) was used as control.
Fig-3: Activation of CD27 signaling pathway. CD27 in the Jurkat/NF-kB/hCD27 Reporter Cell Line was activated by CD70 naturally expressed in Raji cells in a dose-response manner. Note: Jurkat/NF-kB reporter cell line (Abeomics; Cat. No. 14-142ACL) was used as control.
Fig-3: Activation of CD27 signaling pathway. CD27 in the Jurkat/NF-kB/hCD27 Reporter Cell Line was activated by CD70 naturally expressed in Raji cells in a dose-response manner. Note: Jurkat/NF-kB reporter cell line (Abeomics; Cat. No. 14-142ACL) was used as control.