STAT5 Leeporter™ Luciferase Reporter-Ba/F3 Cell Line
Product Sizes
1 Vial
£4481.00
14-135ACL-1VIAL
About this Product
- SKU:
- 14-135ACL
- Extra Details:
- The STAT5 Leeporter™ Luciferase Reporter cell line is a stably transfected Ba/F3 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the STAT5 responsive promoter; so that the cell line is designed to measure the transcriptional activity of STAT5. As a transcription factor; Signal Transducer and Activator of Transcription 5 (STAT5) is activated through phosphorylation at tyrosine 694 in response to many cytokines and growth factors including IL-2; IL-3; GM-CSF and prolactin. Aberrant STAT5 activity is closely related to a wide range of human cancers as STAT5 is often found to be constitutively phosphorylated in cancer cells. The phosphorylated STAT5 forms homodimers or heterodimers with other STATs; and the dimers translocate to nucleus in which DNA binding/promoter induction occurs. The STAT5 induction by IL-3 is shown in Figure 1.
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Immediately upon receipt; store in liquid nitrogen.
- Supplier:
- Abeomics
- Type:
- Cells:Cell Lines
- Manufacturer's Data Sheet:14-135ACL_STAT5_BaF3.png
