IL-6 Leeporter™ Luciferase Reporter-NIH 3T3 Cell Line
Product Sizes
1 Vial
£1931.00
14-116ACL-1VIAL
About this Product
- SKU:
- 14-116ACL
- Extra Details:
- The IL-6 Leeporter™ Luciferase Reporter cell line is a stably transfected NIH 3T3 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the IL-6 promoter. As a pleiotropic cytokine; interleukin 6 (IL-6) has pro- and anti-inflammatory roles which is not only involved in normal functions of the immune system; hematopoiesis and metabolism but also involved in the pathogenesis of metabolic and cardiovascular diseases. IL-6 gene induction is generally regulated by several transcription factors that activate the consensus sequences in the IL-6 promoter region; which include AP-1; C/EBP-beta and NF-kB in response to various proinflammatory cytokines; growth factors; and pathogen-associated molecular patterns such as Toll-like receptor (TLR) ligands. The IL-6 induction by lipopolysaccharide (LPS); the TLR4 ligand as well as by a proinflammatory cytokine; IL-6; is shown in Figures 1 and 2.
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Immediately upon receipt; store in liquid nitrogen.
- Supplier:
- Abeomics
- Type:
- Cells:Cell Lines
- Manufacturer's Data Sheet:14-116ACL_IL-6_NIH3T3_F1-2.png
