Anti-CL2A(ADC linker) antibody(1H2); Rabbit mAb
Product Sizes
10 µg
£490.00
12-9549-10UG
100 µg
£801.00
12-9549-100UG
About this Product
- SKU:
- 12-9549
- translate.label.attr.clone:
- 1H2
- Clonality:
- Monoclonal
- Extra Details:
- Description :Anti-CL2A(ADC linker) antibody(1H2); Rabbit mAbCL2A is a crucial component in antibody-drug conjugate (ADC) therapy; acting as a chemical linker that connects a potent DNA topoisomerase I inhibitor; SN-38; to an antibody. Representing Cysteine-Linked 2-Aminoethyl; CL2A features a complex structure with a PEG8 chain; a triazole ring; a PABC-peptide; and a maleimide group. The maleimide group binds to a cysteine residue on the antibody; facilitating targeted drug delivery. Designed to release SN-38 in acidic cancer cell environments; CL2A induces DNA damage and cell death. This versatile linker is employed in ADCs targeting various antigens like Trop-2 or HER2; tailored to specific cancer types.
- Host:
- Rabbit
- Isotype:
- Rabbit IgG
- Purification:
- Purified from cell culture supernatant by affinity chromatography
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20[o]C to -80[o]C for 12 months in lyophilized form. After reconstitution; if not intended for use within a month; aliquot and store at -80[o]C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
