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Antibodies

Anti-BCL2L1 antibody(DM189); Rabbit mAb

Product Sizes
100 µg
£801.00
12-9360-100UG
About this Product
SKU:
12-9360
Additional Names:
Bcl-X; BCL-XL/S; BCL2L; BCLX; PPP1R52
translate.label.attr.clone:
DM189
Clonality:
Monoclonal
Extra Details:
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane; and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential; and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria; both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.
Host:
Rabbit
Purification:
Purified from cell culture supernatant by affinity chromatography
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Store at -20[o]C for 12 months (Avoid repeated freezing and thawing)
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
  • Manufacturer's Data Sheet:1.jpg
Figure 1. BCL2L1 protein is highly expressed on the surface of Expi293 cell membrane. Flow cytometry analysis with Anti-BCL2L1 (DM189) on Expi293 cells transfected with human BCL2L1 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram); and Isotype antibody on Expi293 transfected with irrelevant protein (Orange histogram).