Biotinylated Anti-CD33 antibody(DM77); Rabbit mAb
Product Sizes
100 µg
£1001.00
12-9251-B-100UG
About this Product
- SKU:
- 12-9251-B
- Additional Names:
- CD33;SIGLEC3;gp67;SIGLEC-3
- translate.label.attr.clone:
- DM77
- Clonality:
- Monoclonal
- Extra Details:
- Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Preferentially recognizes and binds alpha-2;3- and more avidly alpha-2;6-linked sialic acid-bearing glycans. Upon engagement of ligands such as C1q or syalylated glycoproteins; two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. In turn; these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules. One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K.
- Format:
- Liquid
- Host:
- Rabbit
- Purification:
- Purified from cell culture supernatant by affinity chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2 [o]C-8 [o]C for 6 months
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
