Skip to content

Basket

You currently have no items in your basket.

Total (excl. vat) £0.00
View basket & checkout
Antibodies

Anti-HER2 antibody(DMC369); IgG1 Chimeric mAb

Product Sizes
100 µg
£801.00
12-9237-100UG
About this Product
SKU:
12-9237
Additional Names:
ERBB2;CD340;HER-2/neu;HER2;MLN19;NEU;NGL;TKR1
translate.label.attr.clone:
DMC369
Clonality:
Monoclonal
Extra Details:
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However; it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer; stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways; such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported; with the most common allele; Ile654/Ile655; shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers; including breast and ovarian tumors. Alternative splicing results in several additional transcript variants; some encoding different isoforms and others that have not been fully characterized.
Host:
Rabbit
Purification:
Purified from cell culture supernatant by affinity chromatography
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Store at -20[o]C for 12 months (Avoid repeated freezing and thawing)
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
  • Manufacturer's Data Sheet:1.jpg
Figure 2. Flow cytometry analysis of antigen binding of anti-human her2 mAb. (A) Anti-human her2 mAb does not bind to Jurkat cells that do not express her2. (B) A clear peak shift of anti-human her2 mAb was seen compared to the control when incubated with her2-expressing MCF-7 cells; indicating strong binding of anti-human her2 mAb to her2. Antibodies were incubated at 2 µg/mL.
Figure 2. Flow cytometry analysis of antigen binding of anti-human her2 mAb. (A) Anti-human her2 mAb does not bind to Jurkat cells that do not express her2. (B) A clear peak shift of anti-human her2 mAb was seen compared to the control when incubated with her2-expressing MCF-7 cells; indicating strong binding of anti-human her2 mAb to her2. Antibodies were incubated at 2 µg/mL.