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Antibodies

Recombinant anti-human-IL-1 beta Antibody (Canakinumab Biosimilar)

Product Sizes
100 µg
£550.00
12-9112-100UG
About this Product
SKU:
12-9112
Additional Names:
Interleukin-1 beta; Catabolin
Clonality:
Monoclonal
Extra Details:
Target: IL-1 Beta Generic name: Canakinumab Product Origin: Recombinant in Human cells Canakinumab is a recombinant; human anti-human-IL-1-² monoclonal antibody that belongs to the IgG1/-º isotype subclass with a molecular mass of 145157 Daltons when deglycosylated. Canakinumab binds to human IL-1-² and neutralizes its inflammatory activity by blocking its interaction with IL-1 receptors; but it does not bind IL-1alpha or IL-1 receptor antagonist (IL-1ra). References: 1. Church LD; McDermott MF: Canakinumab; a fully-human mAb against IL-1beta for the potential treatment of inflammatory disorders. Curr Opin Mol Ther. 2009 Feb;11(1):81-89. 2. Lachmann HJ; et al.: Use of canakinumab in the cryopyrin-associated periodic syndrome. N Engl J Med. 2009 Jun 4;360(23):2416-25. doi:10.1056/NEJMoa0810787
Format:
Purified
Isotype:
human IgG1
Purification:
Purified from cell culture supernatant by affinity chromatography
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Store at -20[o]C. Avoid repeated freeze and thaw cycles.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
Figure 2. Flow cytometry analysis with 1µg/mL Anti-IL1B (canakinumab biosimilar) mAb (Abeomics 12-9112) on Expi293 cells transfected with Human IL1B protein (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
Fig. 3: Coomassie staining of SDS-PAGE gel loaded with Anti-IL-1beta (Canakinumab biosimilar) mAb.
Fig. 3: Coomassie staining of SDS-PAGE gel loaded with Anti-IL-1beta (Canakinumab biosimilar) mAb.