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Antibodies

Anti-4-1BB Ligand antibody(DM68); Rabbit mAb

Product Sizes
100 µg
£801.00
12-9054-100UG
About this Product
SKU:
12-9054
Additional Names:
4-1BB Ligand;TNFSF9;CD137L
translate.label.attr.clone:
DM68
Clonality:
Monoclonal
Extra Details:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB; which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene; TNFSF9/4-1BBL; has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines; and is thought to be involved in T cell-tumor cell interaction.
Host:
Rabbit
Immunogen:
Recombinant human 4-1BB Ligand (Pro52-Glu254) produced by using human HEK293 cells
Isotype:
Rabbit IgG
Purification:
Purified from cell culture supernatant by affinity chromatography
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Store at -20[o]C for 12 months (Avoid repeated freezing and thawing)
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
  • Manufacturer's Data Sheet:1.jpg
Figure 2. Expi 293 cell line transfected with irrelevant protein (A) and human 4-1BB Ligand (B) were surface stained with Rabbit anti-4-1BB Ligand monoclonal antibody 1µg/ml (clone: DM68) followed by Alexa 488-conjugated anti-rabbit IgG secondary antibody.
Figure 3. FACS data of serially titrated Rabbit anti-4-1BB Ligand monoclonal antibody (clone: DM68) on Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.
Figure 3. FACS data of serially titrated Rabbit anti-4-1BB Ligand monoclonal antibody (clone: DM68) on Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.