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Antibodies

Anti-BCMA bispecific antibody(DM4)

Product Sizes
100 µg
£794.00
12-9001-100UG
About this Product
SKU:
12-9001
Additional Names:
TNFRSF17; CD269; BCM; BCMA
translate.label.attr.clone:
DM4
Clonality:
Monoclonal
Extra Details:
BiTE bispecific antibody is an Engineered fusion protein constructed from two single-chain variable fragments (scFvs) of different monoclonal antibodies. One of the scFvs will be constructed from an anti-CD3 monoclonal antibody; and the other scFv fragment which linked by a linker region will be made from an anti-Tumor cell specific monoclonal antibody.The B-cell maturation protein (BCMA or BCM) is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes; and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily; member 13b (TNFSF13B/TALL-1/BAFF); and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members; and thus may transduce signals for cell survival and proliferation.
Host:
Rabbit
Immunogen:
Recombinant human BCMA (Met1-Ala54) produced by using human HEK293 cells
Isotype:
Rabbit scfv
Purification:
Purified from cell culture supernatant by affinity chromatography
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Store at -20[o]C for 12 months (Avoid repeated freezing and thawing)
Supplier:
Abeomics
Type:
Antibodies:Biosimilar Antibody
  • Manufacturer's Data Sheet:1.jpg
Figure 2. A: The scheme of Anti-BCMA BiTE molecule. B: Tumor cell killing assay. NCI-H929 cells (stably transfected with luciferase); were incubated with freshly isolated human PBMC; and different concentration of BiTE antibodies constructed from rabbit Anti-Human BCMA/TNFRSF17 Clone DM4 ; or BB2121 originated huC11D5.3 clone (blue line) or a no BCMA binding clone as negative control (black line). After 48hrs incubation; the viable NCI-H929 tumor cells were measured by luciferase activity assay.
Figure 2. A: The scheme of Anti-BCMA BiTE molecule. B: Tumor cell killing assay. NCI-H929 cells (stably transfected with luciferase); were incubated with freshly isolated human PBMC; and different concentration of BiTE antibodies constructed from rabbit Anti-Human BCMA/TNFRSF17 Clone DM4 ; or BB2121 originated huC11D5.3 clone (blue line) or a no BCMA binding clone as negative control (black line). After 48hrs incubation; the viable NCI-H929 tumor cells were measured by luciferase activity assay.