Anti-SARS-CoV-2 Nucleocapsid (N) (Clone NP1-B9) Purified No Carrier Protein
Product Sizes
100 µg
£810.00
12-8472-100UG
500 µg
£1222.00
12-8472-500UG
About this Product
- SKU:
- 12-8472
- Additional Names:
- COV2-NP1-B9; SARS-CoV-2 Nucleocapsid; SARS-CoV-2 Nucleoprotein; Protein N; SARS-CoV N Protein
- translate.label.attr.clone:
- NP1-B9
- Clonality:
- Monoclonal
- Extra Details:
- Specificity: Anti-SARS-CoV-2 Nucleocapsid; clone NP1-B9; specifically targets an epitope on the SARS-CoV-2 nucleocapsid protein. Futhermore; it is reported to bind to the oligomerization domain of the N protein. Antigen Distribution: The nucleocapsid protein is expressed in the internal nucleocapsid of SARS-CoV-2. Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); the causative agent of coronavirus disease 2019 (COVID-19); is an enveloped; single-stranded; positive-sense RNA virus belonging to the Coronaviridae family1. The SARS-CoV-2 genome encodes four essential proteins: the spike (S); envelope (E); membrane (M); and nucleocapsid (N) proteins2. SARS-CoV-2 shares 79.6% identity with the original SARS-CoV2. The N protein is 46 kDa and consists of two highly conserved structural domains; the N-terminal domain (NTD) and C-terminal domain (CTD); connected by a linker region. The NTD and CTD are involved in a couple of primary functions; including RNA binding and self-oligomerization3;4. This results in binding to and packaging of the viral RNA genome into a helical ribonucleoprotein5. The N protein is involved in other critical steps of the viral life cycle; including transcription; replication; and modulating infected cell signaling pathways6;7. The N protein is a suitable candidate for vaccine development and diagnostic assays8 for several reasons. It is abundantly expressed during infection and is highly conserved; sharing 90% amino acid homology with the SARS-CoV N protein9. Furthermore; antibodies9;10 and memory T cells11;12 targeting the N protein are identified in the sera of convalescent COVID-19 patients; demonstrating it as immunogenic. The N protein also suppresses antiviral RNAi; evading the innate immune system13; suggesting its potential value as a targeted therapeutic.
- Host:
- Mouse
- Isotype:
- Human IgG1
- Purification:
- Purity :>=90% monomer by analytical SEC and SDS-PagePreparation : Recombinant antibodies are manufactured in an animal free facility using only in vitro protein free cell culture techniques and are pu
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- This antibody may be stored sterile as received at 2-8[o]C for up to one month. For longer term storage; aseptically aliquot in working volumes without diluting and store at
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
