Anti-SARS-CoV-2 Nucleocapsid (N) (Clone NP1-F3) HRP
Product Sizes
50 µg
£840.00
12-8465-50UG
About this Product
- SKU:
- 12-8465
- Additional Names:
- COV2-NP1-F3; SARS-CoV-2 Nucleocapsid; SARS-CoV-2 Nucleoprotein; Protein N; SARS-CoV N Protein
- translate.label.attr.clone:
- NP1-F3
- Clonality:
- Monoclonal
- Extra Details:
- Specificity: Anti-SARS-CoV-2 Nucleocapsid; clone NP1-F3; specifically targets an epitope on the SARS-CoV-2 nucleocapsid protein. Furthermore; it is reported to bind to the RNA binding domain of the N protein. Antigen Distribution: The nucleocapsid protein is expressed in the internal nucleocapsid of SARS-CoV-2. Background: Coronavirus disease 2019 (COVID-19) is caused by the Coronaviridae family virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)1. SARS-CoV-2 has four structural proteins encoded by its single-stranded; positive-sense RNA genome: the spike (S); envelope (E); membrane (M); and nucleocapsid (N) proteins2. The N protein is a highly conserved 46 kDa protein that shares 90% homology with SARS-CoV3. The N protein has an N-terminal (NTD) and C-terminal domain (CTD); which bind to RNA and self-oligomerize; respectively4;5; forming a helical nucleocapsid structure within the viral envelope6. Other functions of the N protein included viral transcription; replication; and modulating cell signaling pathways7;8. The N protein is abundantly expressed during infection; and antibodies3;9 and memory T cells10;11 targeting the N protein have been identified in convalescent sera. Therefore; the N protein is a target in some vaccines and diagnostic assays12. The N protein also has therapeutic potential; as it evades RNAi-mediated antiviral responses13.
- Isotype:
- Human IgG1
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- This horseradish peroxidase conjugated monoclonal antibody is stable when stored at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
