Anti-SARS-CoV-2 Nucleocapsid (N) (Clone NP1-C5) HRP
Product Sizes
50 µg
£840.00
12-8459-50UG
About this Product
- SKU:
- 12-8459
- Additional Names:
- COV2-NP1-C5; SARS-CoV-2 Nucleocapsid; SARS-CoV-2 Nucleoprotein; Protein N; SARS-CoV N Protein
- translate.label.attr.clone:
- NP1-C5
- Clonality:
- Monoclonal
- Extra Details:
- Specificity: Anti-SARS-CoV-2 Nucleocapsid; clone NP1-C5; specifically targets an epitope on the SARS-CoV-2 nucleocapsid protein. Furthermore; it is reported to bind to the RNA binding domain of the N protein. Antigen Distribution: The nucleocapsid protein is expressed in the internal nucleocapsid of SARS-CoV-2. Background: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 belongs to the Coronaviridae family; and its single-stranded; positive-sense RNA genome shares 79.6% identity with SARS-CoV1. The spike (S); envelope (E); membrane (M); and nucleocapsid proteins (N) are four essential structural proteins of SARS-CoV-22. The 46 kDa N protein is highly conserved and shares 90% homology with SARS-CoV3. Similar to SARS-CoV; SARS-CoV-2 has an N-terminal (NTD) and C-terminal domain (CTD); linked by a linker region. The NTD binds to RNA; while the CTD self-oligomerizes4;5; aiding viral genome packaging into a helical ribonucleoprotein complex6. The N protein also participates in viral transcription; replication; and modulation of cell signaling pathways7;8. Some vaccine and diagnostic assays9 have focused on the N protein as it is highly expressed during infection and activates antibodies3;10 and memory T cells11;12; found in convalescent sera. The N-protein also evades the innate immune system by inhibiting RNAi13; identifying it as a potential therapeutic target.
- Isotype:
- Human IgG1
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- This horseradish peroxidase conjugated monoclonal antibody is stable when stored at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
