Anti-SARS-CoV-2 Nucleocapsid (N) (Clone NP1-E9) Biotin
Product Sizes
50 µg
£771.00
12-8449-50UG
About this Product
- SKU:
- 12-8449
- Additional Names:
- COV2-NP1-E9; SARS-CoV-2 Nucleocapsid; SARS-CoV-2 Nucleoprotein; Protein N; SARS-CoV N Protein
- translate.label.attr.clone:
- NP1-E9
- Clonality:
- Monoclonal
- Extra Details:
- Specificity: Anti-SARS-CoV-2 Nucleocapsid; clone NP1-E9; specifically targets an epitope on the SARS-CoV-2 nucleocapsid protein. Futhermore; it is reported to bind to the oligomerization domain of the N protein. Antigen Distribution: The nucleocapsid protein is expressed in the internal nucleocapsid of SARS-CoV-2. Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); the causative agent of coronavirus disease 2019 (COVID-19); is an enveloped; single-stranded; positive-sense RNA virus that belongs to the Coronaviridae family 1. The SARS-CoV-2 genome; which shares 79.6% identity with SARS-CoV; encodes four essential structural proteins: the spike (S); envelope (E); membrane (M); and nucleocapsid protein (N) 2. The N protein is 46 kDa and consists of two highly conserved structural domains; the N-terminal domain (NTD) and C-terminal domain (CTD); connected by a linker region. The NTD and CTD are involved in RNA binding and self-oligomerization; respectively 3; 4. The primary function of the N protein is to bind to and package the viral RNA genome into a helical ribonucleoprotein complex 5. The N protein is also involved in other critical steps of the viral life cycle; including transcription; replication; and modulating infected cell signaling pathways 6; 7. The N protein is abundantly expressed during infection and is highly conserved; sharing 90% amino acid homology with the SARS-CoV N protein 8. It is also immunogenic; and antibodies 8;9 and memory T cells 10; 11 targeting the N protein are present in the sera of convalescent COVID-19 patients; identifying the N protein as a suitable candidate for vaccine development and diagnostic assays. Diagnostic assays based on the N protein effectively detect antibodies in the sera of patients infected with SARS-CoV-2 12. The N protein also contributes to immune evasion by antagonizing antiviral RNAi 13; suggesting its potential value as a targeted therapeutic.
- Host:
- Mouse
- Isotype:
- Human IgG1
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- This bioinylated antibody is stable when stored at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
