Anti-SARS-CoV-2 Spike NTD (Clone 2146)- Purified No Carrier Protein
Product Sizes
100 µg
£635.00
12-8427-100UG
500 µg
£867.00
12-8427-500UG
About this Product
- SKU:
- 12-8427
- Additional Names:
- COV2-2146; SARS-CoV2 Spike NTD; COVID-19; 2019-nCoV; Severe acute respiratory syndrome coronavirus 2; SARS-CoV2
- Clonality:
- Monoclonal
- Extra Details:
- Specificity: Anti-SARS-CoV-2 Spike NTD; clone 2146; specifically targets an epitope on the SARS-CoV-2 spike protein N-terminal domain. Antigen Distribution: The spike NTD is expressed on the surface of SARS-CoV-2. Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); the causative agent of coronavirus disease 2019 (COVID-19); is an enveloped; single-stranded; positive-sense RNA virus that belongs to the Coronaviridae family 1. The SARS-CoV-2 genome; which shares 79.6% identity with SARS-CoV; encodes four essential structural proteins: the spike (S); envelope (E); membrane (M); and nucleocapsid protein (N) 2. The S protein is a transmembrane; homotrimeric; class I fusion glycoprotein that mediates viral attachment; fusion; and entry into host cells 3. Each ~180 kDa monomer contains two functional subunits; S1 (~700 a.a) and S2 (~600 a.a); that mediate viral attachment and membrane fusion; respectively. S1 contains two major domains; the N-terminal (NTD) and C-terminal domains (CTD). In both SARS-CoV and SARS-CoV-2; the CTD contains the receptor-binding domain (RBD); which binds to the angiotensin-converting enzyme 2 (ACE2) receptor on host cells3-5. The NTD of SARS-CoV-2 does not bind to ACE26; and the function of NTD in SARS-CoV-2 infection is not well understood. In other CoVs; the NTD may promote attachment by binding to sugar moieties7 and might play a role in the conformational change of S2 required for membrane fusion8. While most neutralizing antibodies target the RBD domain and block receptor binding; potent neutralizing antibodies targeting NTD were isolated from convalescent COVID19 patients9; identifying the NTD as an attractive candidate for vaccines and therapeutics. In addition; the NTD is a promising antigen for diagnostic tests; as there is only 53.5% homology between the NTD of SARS-CoV-2 and SARS-CoV10.
- Isotype:
- Human IgG1
- Purification:
- Purity :>=90% monomer by analytical SEC and SDS-PagePreparation : Recombinant antibodies are manufactured in an animal free facility using only in vitro protein free cell culture techniques and are pu
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- This antibody may be stored sterile as received at 2-8[o]C for up to one month. For longer term storage; aseptically aliquot in working volumes without diluting and store at
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:1.jpg
