Anti-Enterovirus 68; Capsid (Clone EV-D68-159) Purified No Carrier Protein
Product Sizes
250 µg
£583.00
12-8401-250UG
1 mg
£812.00
12-8401-1MG
About this Product
- SKU:
- 12-8401
- Additional Names:
- EVD68; Enterovirus; VP1; VP3
- Application:
- Electron Microscopy
- translate.label.attr.clone:
- EV-D68-159
- Clonality:
- Monoclonal
- Extra Details:
- Specificity: Clone EV-D68-159 is a human IgG monoclonal antibody specifically binds to VP1 and VP3 of Enterovirus D68; clade B. Antigen Distribution: Enterovirus-D68 (EV-D68) can be found in human respiratory epithelial cells; gastrointestinal cells; and motor neurons within the spinal cord's grey matter?. Background: EV-D68 is a highly transmissible respiratory disease that primarily impacts children. It is among the 100-plus non-polio enteroviruses and is listed as a NIAID Biodefense Priority Pathogen. The respiratory condition can vary from mild (resembling a common cold) to more severe; potentially resulting in acute flaccid myelitis (AFM); a condition characterized by lasting muscle weakness. The majority of individuals with EV-D68 encounter mild symptoms and recuperate without significant complications1. No vaccines are currently accessible for preventing EV-D68 infections; but practical measures can aid in lowering the chances of transmission. The virus is transmitted via respiratory secretions (saliva; nasal mucus; and sputum) when an infected individual coughs; sneezes or makes contact with surfaces subsequently touched by others2. Clone EV-D68-159 light chain CDR1 and CDR3 bind to three residues on the C terminus of VP1(Glu271; Arg272; and Asp285); however; the heavy chain CDR2 and and CDR3 bind the N-terminal loop of VP3 before the B-? strand. The capsid is made up of four viral proteins (VP1; VP2; VP3; and VP4) that are crucial for the virus's ability to bind and enter host cells. Clone EV-D68-159 effectively binds and neutralizes clade B virus; preventing it from infecting cells and spreading4.
- Isotype:
- Human IgG1
- Purification:
- Purity :>=90% monomer by analytical SEC and SDS-PagePreparation : Recombinant antibodies are manufactured in an animal free facility using only in vitro protein free cell culture techniques and are pu
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- This antibody may be stored sterile as received at 2-8[o]C for up to one month. For longer term storage; aseptically aliquot in working volumes without diluting and store at
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
