Anti-SARS-CoV-1; Spike NTD (Clone COV1-65)-Purified No Carrier Protein
Product Sizes
250 µg
£583.00
12-8260-250UG
1 mg
£812.00
12-8260-1MG
About this Product
- SKU:
- 12-8260
- translate.label.attr.clone:
- COV1-65
- Clonality:
- Monoclonal
- Extra Details:
- Specificity: COV1-65 targets the N-terminal domain (NTD) of the SARS-CoV-1 prefusion spike protein; distributed on the viral surface. Antigen Distribution: Anti-SARS-CoV-1 recognizes antigens on infected cells; including respiratory epithelial cells. Background: SARS-CoV-1; also known as the Severe Acute Respiratory Syndrome coronavirus; is a zoonotic virus that is believed to have originated from an animal reservoir; possibly horseshoe bats; and transmitted to humans1. This virus primarily affects the respiratory system and can cause symptoms such as muscle pain; headache; fever; cough; dyspnea; and pneumonia1;2. It was the first severe and readily transmissible new disease to emerge in the 21st century; with the capacity to spread globally via international air travel. COV1-65 is a monoclonal antibody specific to the N-terminal domain (NTD) of the SARS-CoV-1 spike protein. Unlike antibodies targeting the RBD; COV1-65 does not block the ACE2 receptor but does function as a neutralizer. The NTD is important for the virus's structural integrity and function; and targeting this domain could disrupt the viral life cycle in other ways. COV1-65's binding to the NTD suggests it could be useful in inhibiting viral attachment or fusion indirectly or in combination with other neutralizing antibodies; providing a broader approach to preventing infection.
- Isotype:
- Human IgG1 L
- Purification:
- Purity: >=90% monomer by analytical SEC and SDS-Page Preparation: Recombinant antibodies are manufactured in an animal free facility using only in vitro protein free cell culture techniques and are pu
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- This antibody may be stored sterile as received at 2-8[o]C for up to one month. For longer term storage; aseptically aliquot in working volumes without diluting and store at
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Manufacturer's Data Sheet:download_pdf.php
